Despite an overall improvement of air quality in the state of North Carolina during the past two decades, sporadic yet continuing episodes of exposure to poor air quality in the areas where minority groups reside have been a concern to public health. In most air exposure and risk assessment studies, unfortunately, the focus has been on the quantity of exposure and health outcomes. Interpretation of health outcome studies by using current collection mode for ICD-9 and ICD-10 as well as particulate matter (PM) mass cannot exclude inevitable systematic errors. Complexity present in air exposure/risk assessment studies also lies on the fact that the components of air pollutants are not universally consistent. In our two-year long Pilot Study, we intend to achieve a goal of better understanding if the PM components from minority communities are different from those from non- minority community and if the different chemistry induces different pathological conditions.